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DDIT3

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DDIT3

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DDIT3

DNA damage-inducible transcript 3

(CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. It is a member of the CCAAT/enhancer-binding protein (C/EBP) family

Liposarcoma

by their expression of a FUS-DDIT3 fusion gene (also termed a chimeric gene) which occurs in >95% of cases or a EWSR1-DDIT3 fusion gene which occurs in

Myxoid liposarcoma

two fusion genes: the FUS-DDIT3 in ~90% and the EWSR1-DDIT3 fusion gene in up to 10% of myxoid liposarcoma cases. The FUS-DDIT3 fusion gene forms by a merger

Down syndrome

Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar

Receptor (biochemistry)

c-Jun JUNB JunD BACH 1 2 BATF BLZF1 C/EBP α β γ δ ε ζ CREB 1 3 L1 CREM DBP DDIT3 GABPA GCN4 HLF MAF B sMaf F G K NFE 2 L1 L2 L3 NFIL3 NRL NRF 1 2 3 XBP1

Turner syndrome

Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar

Birth defect

Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar

Clear cell sarcoma

fusion gene in a majority of cases or a EWSR1-CREB1, EWSR1-CREM, or EWSR1-DDIT3 fusion gene in a small subset of cases (see FET gene family of fusion genes)

Protein c-Fos

c-Fos has been shown to interact with: BCL3, COBRA1, CSNK2A1, CSNK2A2, DDIT3, JUN NCOA1, NCOR2, RELA, RUNX1, RUNX2, SMAD3, and TBP. Leptomycin c-Jun

Miscarriage

Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar