The acronym NPOYM(2) means : NPOYM literally stands for 'Naked Picture of your Mother'. When used as a tool to 'cut someone down', it can be very effective.
Jim: "Hey Larry, your mamma so fat she has her own zip code!"
Larry: "Yo momma so ugly they had to tie a pork chop around her neck to get the dog to play with her!"
Jim: "Hey Larry, wanna buy an NPOYM? They're going fast. Almost sold out right here in school!"
Larry: "What's an NPOYM?"
Jim: "An NPOYM is a Naked Picture of your Mom!? They're only $5 each!"
Larry: "That's fucked up Jim. You got me good that time!"
Jim: "Well, do you want one? I've got an assortment actually! Check out all the NPOYM's I've got!"
Acronyms, abbreviations and meanings similar to NPOYM
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F means: Fahrenheit
PMS means: Platform Management System
BIOS means: Biological Data System (file Within STORET)
MC means: Mission Completion/Continuation
PGS means: Power Generation Subsystem